The invention relates to aqueous saline solutions with an osmolarity of 50 mOsm/L to 170 mOsm/L, which further include at least one membrane-weakening agent. The invention also relates to a cosmetic composition which includes one of said solutions, as well as to the use of one of said solutions to obtain a drug for treating cellulite, steatomery, and lipomas.Linvention concerne des solutions salines aqueuses dosmolarité comprise entre 50 mOsm/L et 170 mOsm/L, qui comprennent en outre au moins un fragilisant membranaire. L invention concerne aussi une composition cosmétique qui comprend une de ces solutions, ainsi que lutilisation dune de ces solutions pour lobtention dun médicament destiné au traitement de la cellulite, de la stéatomérie ainsi que du lipome.