The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.本發明係關於嵌合及人類化抗體,及用於治療及診斷與類澱粉蛋白相關的類澱粉變性、病症及異常如阿茲海默氏症(Alzheimer's disease)之方法及組合物。