The University Of Western Australia;Sanford Burnham Prebys Medical Discovery Institute
发明人:
HAMZAH, Juliana Binti,GANSS, Ruth Annelore,RUOSLAHTI, Erkki,BILIRAN JR., Hector R.
申请号：
EP17740910
公开号：
EP3405209A4
申请日:
2017.01.19
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Provided herein are biomolecule conjugates, and methods of use thereof, wherein the conjugate comprises a cytokine, typically an immunopotentiating cytokine, and a peptide comprising or consisting of the sequence CSGRRSSKC (SEQ ID NO:1). Biomolecule conjugates of the invention find application, inter alia, in the treatment of turnouts, atherosclerosis and fibrosis, and the degradation of ECM associated therewith. Also provided herein are uses of a peptide comprising or consisting of the sequence of SEQ ID NO:1, optionally linked to a delectable agent and/or a carrier, in the detection and/or localisation of tumour, atherosclerotic and fibrotic tissue.
