Disclosed are substituted phenoxy N-alkylated thiazolidinediones represented by general formula (I), or optical isomers, enantiomers, diastereomes, cis-trans isomers, racemates or pharmaceutically acceptable salts thereof, such as 4-{ 2-Methoxy-4-[3-(2-morpholin-4-yl-ethyl)-2,4-dioxo-thiazolidin-5-ylidenemethyl]-phenoxy} -3-trifluoromethyl-benzonitrile. Also disclosed is the use of the compounds of formula (I) for treating a disease, disorder or condition such as bone-related disease, bone formation, cartilage formation, cartilage loss, cartilage degeneration, cartilage injury, ankylosing spondylitis, chronic back injury, gout, osteoporosis, osteolytic bone metastasis, multiple myeloma, chondrosarcoma, chondrodysplasia, osteogenesis imperfecta, osteomalacia, Paget's disease, polymyalgia rheumatica, pseudogout, arthritis, rheumatoid arthritis, infectious arthritis, osteoarthritis, psoriatic arthritis, reactive arthritis, childhood arthritis, Reiter's syndrome, and repetitive stress injury.
