GAUL, MICHAEL,KIM, ALEXANDER,SEARLE, LILY LEE,RENTZEPERIS, DIONISIOS,BIGNAN, GILLES C
申请号：
NZ57941708
公开号：
NZ579417A
申请日:
2008.03.06
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed are phenoxy aminothiazolones represented by general formula (I), or pharmaceutically acceptable salts, optical isomers, enantiomers, diastereomers, cis-trans isomers or racemates. An example of a compound of formula (I) is 4-[4-(2-Amino-4-oxo-4H-thiazol-5-ylidenemethyl)-2-methoxy-phenoxy]-3-trifluoromethyl-benzonitrile. Also disclosed is the use of the compounds for treating bone-related disease, bone formation, cartilage formation, cartilage loss, cartilage degeneration, cartilage injury, ankylosing spondylitis, chronic back injury, gout, osteoporosis, osteolytic bone metastasis, multiple myeloma, chondrosarcoma, chondrodysplasia, osteogenesis imperfecta, osteomalacia, Pagets disease, polymyalgia rheumatica, pseudogout, arthritis, rheumatoid arthritis, infectious arthritis, osteoarthritis, psoriatic arthritis, reactive arthritis, childhood arthritis, Reiters syndrome, repetitive stress injury, periodontal disease, chronic inflammatory airway disease, chronic bronchitis, chronic obstructive pulmonary disease, metabolic syndrome, obesity, disorders of energy homeostasis, diabetes, lipid disorders, cardiovascular disorders, artherosclerosis, hyperglycemia, elevated blood glucose level, and insulin resistance.
