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PRINTABLE MORPHOGENETIC PHASE-SPECIFIC CHITOSAN-CALCIUM-POLYPHOSPHATE SCAFFOLD FOR BONE REPAIR
专利权人:
发明人:
申请号:
EP15748200.1
公开号:
EP3171902A1
申请日:
2015.07.24
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
This invention concerns a formula for the synthesis of a printable hybrid material, formed of carboxymethyl chitosan (CMC) and polyphosphate (polyP). Both polymers are linked together by calcium ions. The inventive CMC-polyP material, in combination with alginate, is biocompatible, biodegradable and useful for three-dimensional (3D) printing and 3D cell printing (bioprinting). The CMC-polyP scaffold, hardened by exposure to calcium ions, is morphogenetically active and can be used in bone tissue engineering, as a biomimetic 3-phase scaffold that mimics and induces essential phases in bone repair, including blood clot formation and platelet degranulation (release of growth factors and cytokines) (Phase 1: initiation phase), calcium carbonate bioseed formation (Phase 2: nucleation) and expression / activation of bone alkaline phosphatase (Phase 3: hydroxyapatite biomineral formation).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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