WERNER ERNST LUDWIG GEORG MULLER,HEINRICH-CHRISTOPH WILHELM FRIEDRICH SCHRODER,XIAOHONG WANG
申请号：
GB201413154
公开号：
GB2528504A
申请日:
2014.07.24
申请国别(地区):
GB
年份:
2016
代理人:
摘要：
This invention concerns a formula for the synthesis of a printable hybrid material, formed of carboxymethyl chitosan (CMC) and polyphosphate (polyP). Both polymers are linked together by calcium ions. The inventive CMC-polyP material, in combination with alginate, is biocompatible, biodegradable and useful for three-dimensional (3D) printing and 3D cell printing (bioprinting). The CMC-polyP scaffold, hardened by exposure to calcium ions, is morphogenetically active and can be used in bone tissue engineering, as a biomimetic 3-phase scaffold that mimics and induces essential phases in bone repair, including blood clot formation and platelet degranulation (release of growth factors and cytokines) (Phase 1: initiation phase), calcium carbonate bioseed formation (Phase 2: nucleation) and expression / activation of bone alkaline phosphatase (Phase 3: hydroxyapatite biomineral formation).
