The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
Rosenberg, Steven A.,Chinnasamy, Dhanalakshmi
申请号：
AU2010301042
公开号：
AU2010301042A1
申请日:
2010.09.14
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of a KDR-1121 or DC101 antibody, an extracellular hinge domain, a T cell receptor transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.
