Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptor and its use for the treatment of cancer

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专利权人:

アメリカ合衆国

发明人:

ローゼンバーグ、スティーヴン エー．,チナサミー、ダナラクシュミ,ローゼンバーグ、スティーヴン エー.

申请号：

JP2012532100

公开号：

JP5934099B2

申请日:

2010.09.14

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of a KDR-1121 or DC101 antibody, an extracellular hinge domain, a T cell receptor transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/