A method of manufacturing a wire for straightening irregular teeth, which is not harmful to a human body and preserves the color of the teeth, is provided. The method of manufacturing a wire for straightening irregular teeth includes manufacturing a metal wire with metal alloy physically or chemically etching a surface of the metal wire and then performing heat treatment coating the surface of the metal wire with a metal material, Teflon, epoxy or urethane to show white or ivory and then performing heat treatment forming a transparent parylene film on the metal material, Teflon, epoxy or urethane and then performing heat treatment and removing one side of the foregoing coating layer from the surface of the metal wire, and then applying surface treatment to the one side with the coating layer removed.
