A valve box for irrigation systems is described, comprising a box-shaped body closed by a lid, and a plurality of electro-valves contained in an inner compartment of said box-shaped body and adapted to allow a fluid from a supply conduit to flow towards a plurality of outlet conduits, each being controlled by an electrovalve. The valve box comprises a single programmable drive and control module of said electrovalves which is contained in a containment box releasably secured above said compartment.