PROBLEM TO BE SOLVED: To provide a device for percutaneous transdermal delivery of a potent pharmacologically active agent, in a transdermal drug delivery system for administering strong potent pharmacologically active agent through a stratum corneum epidermidis using skin piercing microprotrusions having a dry film of pharmacologically active material.SOLUTION: This device includes a member 14 having a plurality of corneum layer-piercing microprotrusions 12 and the dry film 12 on the member, wherein the film contains a fixed quantity of an aqueous solution of pharmacologically active material before drying. In the case of dosage of under 1 mg of pharmacologically active material, it is enough strong to be effective in treatment, the material has water solubility exceeding about 50 mg/ml, and the aqueous solution has the viscosity of under about 500 centipoise.COPYRIGHT: (C)2007,JPO&INPIT【課題】薬理学的活性物質を経皮的に配達する。【解決手段】複数の角質層-穿刺微細突出物12を有する部材14、および部材上の乾燥被膜12を含んでおり、当該被膜は乾燥前に、一定量の薬理学的活性物質の水溶液を含んでいる成る装置。前記薬理学的活性物質が約1mg未満の量を投与される時に治療的に有効であるほど十分に強力であり、前記物質が約50mg/mlを超える水溶性を有し、かつ前記水溶液が約500センチポアズ未満の粘度を有する。【選択図】図1
