LÍGIA SANTOS PEDROSO,NAJEH MAISSAR KHALIL,RUBIANA MARA MAINARDES
申请号：
BR102017010928
公开号：
BR102017010928A2
申请日:
2017.05.24
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The production process of bovine albumin nanoparticles containing amphotericin B and coated with polysorbate 80 by the method of coacervação.The present invention includes the production of bovine albumin nanoparticles containing amphotericin B, coated with polysorbate 80 by the method of coacervação,As an alternative strategy for carting the drug.This invention provides the development of nanoparticles with control of the size and capacity of encapsulation of amphotericin B,In addition to optimize the physical and chemical properties so as to promote stability in physiological media, increase the bioavailability.To provide a distribution site - specific and reduce the toxicity.The nanoparticles of bovine albumin containing amphotericin B coated with polysorbate 80 are set of properties that make it a significant model for efficient nanocarreadoresTreatment of fungal infections in the central nervous system since they are coated superficially by surfactant, polysorbate 80,Which has among its features the ability to facilitate transport through the blood-brain barrier.In this context, the present invention aims to optimize the physical and chemical properties, increasing the bioavailability and in vivo targeting of amphotericin B,In order to reduce the toxic effects contributing to adherence to treatment, for application in drug therapy of fungal infections.processo de produção de nanopartículas de albumina bovina contendo anfotericina b e revestidas com polisorbato 80 pelo método de coacervação. a presente invenção compreende o processo de produção de nanopartículas de albumina bovina contendo anfotericina b, revestidas com o polisorbato 80 pelo método de coacervação, como estratégia alternativa para carreamento do fármaco. esta invenção propicia o desenvolvimento de nanopartículas com controle do tamanho e da capacidade de encapsulação da anfotericina b, além de otimizar as propriedades físico-químicas de forma a promover a estabilidade em meios fisiológicos, aumen
