Artur Martynov,Boris S. Farber,Sonya Sophya Farber
申请号：
US14140489
公开号：
US20150174208A1
申请日:
2013.12.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention is a cosmetic and pharmaceutical liposomal composition which comprises a mixture of carboxylated oligopeptides derived from natural polypeptides insulin hyaluronidase and collagenase by their enzymatic hydrolysis followed by a carboxylation of the free amino groups of lysine, histidine, and additional hydrolysis of terminal amino groups in the oligopeptides. Natural polypeptides may be hydrolyzed with a proteolytic enzyme to form a mixture of oligopeptides and succinylated them. Next, the resulting mixture was injected into the liposomes by classical methods to improve the intestinal absorption and bioavailability in the body, prolonging the action of the system. Such a system behaves as quasi-live and is capable of forming supramolecular complexes with the original proteins, such as insulin and acylated insulin oligopeptides, or insulin receptors on a cell and acylated insulins oligopeptides. These cosmetic formulations may be used as prophylactic and therapeutic drugs in the prevention of infectious diseases as do vaccines in the treatment of cancer pancreatitis and other diseases rejuvenation of skin and body and acceleration of wound healing.
