ПЕРКИНС Вальтер (US),МАЛИНИН Владимир (US),ЛИ Сингун (US),МИЛЛЕР Брайан (US),ЗАЙДЕЛЬ Доминик (DE),ХОЛЬЦМАНН Филипп (DE),ШУЛЬЦ Харальд (DE),ХАН Михаэль (DE)
申请号：
RU2014151554
公开号：
RU2014151554A
申请日:
2013.05.21
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A system for treating or providing prophylaxis against pulmonary infection in a patient, comprising: (a) a pharmaceutical composition comprising an aminoglycoside in the liposome complex, the composition being an aqueous dispersion, and the lipid component of the liposome is composed of electrically neutral lipids, and ( b) a nebulizer that generates an aerosol of pharmaceutical composition at a rate of more than about 0.53 g per minute, with a mass-median aerodynamic diameter (MMAD) of the aerosol of less than about 4.2 microns, respectively Corollary to measured via Anderson Cascade Impactor (ACI), or less than about 4.9 microns, measured in accordance with a next generation via Impactor (NGI) .2. A system for treating or providing prophylaxis against pulmonary infection, comprising: (a) a pharmaceutical composition containing an aminoglycoside in the liposome complex, the composition being an aqueous dispersion, and the lipid component of the liposome consists of electrically neutral lipids, and (b) a nebulizer, which generates an aerosol of pharmaceutical composition at a rate of more than about 0.53 g per minute, with a fraction of aerosol fines (FPF) of about 64% or more, as measured by ACI, or 51% or more, as measured by NGI. 3. The system of Claim 1, wherein the aminoglycoside is selected from amikacin, apramycin, arbekacin, astromycin, capreomycin, dibecacin, framycetin, gentamycin, hygromycin B, isepamycin, kanamycin, neomycin, netilomycin, paromethomycin, rodreptomycin, rodestreptomycin, rodestreptomycin, rodestreptomycin, rodestreptomycin, rodestreptomycin, rodestreptomycin, rodreptomycin, rodreptomycin, tobramycin, verdamycin, or a combination thereof. 4. System for1. Система для лечения или обеспечения профилактики против легочной инфекции у пациента, содержащая:(a) фармацевтический состав, содержащий аминогликозид, находящийся в липосомальном комплексе, при этом состав представляет собой водную дисперсию, и липидный компонент липосомы состоит из эл
