CARBOHYDRATE-DERIVATIZED LIPOSOMES FOR TARGETING CELLULAR CARBOHYDRATE RECOGNITION DOMAINS OF CTL/CTLD LECTINS, AND INTRACELLULAR DELIVERY OF THERAPEUTICALLY ACTIVE COMPOUNDS
GIESELER, ROBERT K.,MARQUITAN, GUIDO,SCOLARO, MICHAEL J.,SCHWARZ, ANDREAS
申请号：
CA2560241
公开号：
CA2560241C
申请日:
2005.03.21
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Methods for preferentially delivering an active agent intracellularly to areservoir cell that is infected with or susceptible to infection with aninfectious agent, such as HIV. The active agent is part of a lipid-activeagent complex that has a targeting ligand, such as a CTL/CTLD receptor-specific anchor, on its outer surface. Targeting systems are also disclosed.Such targeting systems are comprised of lipid-active agent complexes thatcontain targeting ligands, such as fucose and polyfucose derivatives, on theirouter surfaces. The active agents include plant lectins, such as Con-A andMHL, and other drugs. Such methods and targeting systems may be used in thetreatment of HIV and other infectious and non-infectious diseases.
