Carbohydrate-derived liposomes destined to target cellular carbohydrate recognition domains of CTL / CTLD lecithins as well as intracellular delivery of therapeutically active compositions
MARQUITAN, GUIDO,SCOLARO, MICHAEL J.,SCHWARZ, ANDREAS,GIESELER, ROBERT K.
申请号：
DK05725950
公开号：
DK1761248T3
申请日:
2005.03.21
申请国别(地区):
DK
年份:
2012
代理人:
摘要：
Methods for preferentially delivering an active agent intracellularly to a reservoir cell that is infected with or susceptible to infection with an infectious agent, such as HIV. The active agent is part of a lipid-active agent complex that has a targeting ligand, such as a CTL/CTLD receptor-specific anchor, on its outer surface. Targeting systems are also disclosed. Such targeting systems are comprised of lipid-active agent complexes that contain targeting ligands, such as fucose and polyfucose derivatives, on their outer surfaces. The active agents include plant lectins, such as Con-A and MHL, and other drugs. Such methods and targeting systems may be used in the treatment of HIV and other infectious and non-infectious diseases.
