A medical information processing system according to an embodiment includes processing circuitry. The processing circuitry is configured to identify the position of a tissue from first medical image data represented by an image of a target site acquired before the tissue in the target site was collected and to obtain an image feature value of the tissue. The processing circuitry is configured to obtain an examination result of a pathological examination performed on the tissue. The processing circuitry is configured to bring the image feature value of the tissue into association with the examination result of the pathological examination.