PARK, YOUNG JOON,박영준,SHIN, MYUNG JIN,신명진,JIN, HONG CHUL,진홍철,CHOI, HA YONG,최하용,CHOI, NAK HYUN,최낙현
申请号：
KR1020120137375
公开号：
KR1012606360000B1
申请日:
2012.11.29
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A stabilized pemetrexed agent is provided to prevent discoloration or sediment generation by containing acetylcysteine as an antioxidant and sodium citrate as a buffer agent. CONSTITUTION: A stabilized pemetrexed agent comprises pemetrexed or pharmaceutically allowable salt thereof as an active ingredient, N-acetyl-L-cysteine ,and sodium citrate. The concentration ratio of pemetrexed or pharmaceutically allowable salt thereof, N-acetyl-L-cysteine, and sodium citrate is 1-30:0.15-2.0:1.0-15.0. The agent is stored in a solution state. The agent is a liquid formulation for injection contained in a sealed ready-to-use container. [Reference numerals] (AA) Injection water(WFI)； (BB) Example 11； (CC) Comparative example 12； (DD) Comparative example 14； (EE) Comparative example 1본 발명은 안정화된 페메트렉시드 제제에 관한 것으로, 더욱 상세하게는 항산화제로서 아세틸시스테인을 포함하고 완충제로서 시트르산 나트륨을 포함하는 안정화된 페메트렉시드 제제에 관한 것이다.
