PROBLEM TO BE SOLVED: To provide an injection formulation which can suppress decomposition and coloring of pemetrexed or a salt thereof during storage, and to provide a production method thereof.SOLUTION: The invention provides an injection formulation containing (i) pemetrexed or a salt thereof (ii) at least one kind selected from the group consisting of sulfurous acid or a salt thereof, hydrogen sulfite or a salt thereof, pyrosulfurous acid or a salt thereof, nitrous acid or a salt thereof, sulfur dioxide, and thiosulfuric acid or a salt thereof and (iii) 50 mass% or more of an aqueous solvent to the total mass of the injection formulation and having pH of more than 6.0 and to provide a production method thereof.COPYRIGHT: (C)2015,JPO&INPIT【課題】保管中のペメトレキセド又はその塩の分解と着色とを抑制し得る注射液製剤及びその製造方法の提供。【解決手段】(i)ペメトレキセド又はその塩、(ii)亜硫酸又はその塩、亜硫酸水素又はその塩、ピロ亜硫酸又はその塩、亜硝酸又はその塩、二酸化硫黄、及びチオ硫酸又はその塩からなる群より選ばれる少なくとも1種、並びに(iii)注射液製剤の全質量に対して50質量%以上の水性溶媒を含み、かつ、pHが6.0を超える注射液製剤及びその製造方法。【選択図】なし
