PROBLEM TO BE SOLVED: To provide compositions for at least one of: increase in melatonin synthesis; promotion of melatonin secretion; treatment of diseases associated with neurometabolic disorder; prevention of diseases associated with neurometabolic disorder; appetite control; mood control; vasoconstriction control; hemostasis control; and immune response regulation.SOLUTION: Disclosed herein is a composition comprising hydroxyanigorufine.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】メラトニン合成の増加、メラトニン分泌の促進、神経代謝障害に関連する疾患の治療、神経代謝障害に関連する疾患の予防、食欲制御、気分制御、血管収縮制御、止血機能制御、及び免疫応答制御のうち少なくとも1つのための組成物の提供。【解決手段】ヒドロキシアニゴルホンを含んでなる組成物。【選択図】なし