PROBLEM TO BE SOLVED: To provide a substance useful for such purposes as promoting GLP-1 secretion, suppressing glucagon secretion, suppressing appetite, or preventing and/or mitigating post-prandial hyperglycemia, and illnesses or conditions such as diabetes.SOLUTION: A GLP-1 secretagogue contains a LPI (lysophosphatidylinositol) or salt thereof as an active constituent. A glucagon secretion inhibiter contains the LPI or salt thereof as an active constituent. An appetite suppressor contains the LPI or salt thereof as an active constituent. A preventing and/or mitigating agent of post-prandial hyperglycemia contains the LPI or salt thereof as an active constituent. A preventing and/or mitigating agent of diabetes contains the LPI or salt thereof as an active constituent.COPYRIGHT: (C)2012,JPO&INPIT【課題】GLP-1分泌促進、グルカゴン分泌抑制、食欲抑制、又は食後高血糖、糖尿病等の疾患若しくは状態の予防及び/又は改善等に有用な物質の提供。【解決手段】LPI又はその塩を有効成分とするGLP-1分泌促進剤。LPI又はその塩を有効成分とするグルカゴン分泌抑制剤。LPI又はその塩を有効成分とする食欲抑制剤。LPI又はその塩を有効成分とする食後高血糖予防及び/又は改善剤。LPI又はその塩を有効成分とする糖尿病予防及び/又は改善剤。【選択図】なし