A method of inhibiting a histone deacetylase activity, comprising administering to a recipient subject in need thereof a composition that contains an effective amount of small somatic stem cells that are greater than 2 micrometers and less than 6 micrometers in size, wherein the small somatic stem cells include CD349+ somatic stem cells and Lgr5+ somatic stems cells.一種抑制組蛋白去乙醯酶活性之方法，其包含對一有需要的受試者投予一組成物，該組成物含有一有效量之尺寸大於2微米以及小於6微米之小型成體幹細胞，其中該小型成體幹細胞包括CD349+成體幹細胞以及Lgr5+成體幹細胞。
