COMMERÇON ALAIN,GAUZY-LAZO, LAURENCE,HUBERT, PHILIPPE
申请号：
PE0001352013
公开号：
PE04892013A1
申请日:
2011.07.25
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to conjugated dimers pirrolo [1,4] benzodiazepine of formula (i) where u and u are absent or are each h W and W are each h, Oh, sh, CN, halogen, among others R1 and R2 and R1 and R2 together form a double Bond OR = CH2 = CH - CH3 or are each h, halogen or alkyl (C1 - C6) ALK and ALK are alquileno (C1 - C6) and are each H U - or, where R and R are each h,(C1 - C6 alkyl or aryl optionally replaced with Halogen, CN, CF3, among others M is CH or N K is from 0 to 40 L1 is a simple Link, D - ALK (C1 - C6) attached to the phenyl or pyridinyl Cycle, among others, where d is o, NH or N - alkyl (c1-c4) L2 is ALK (C1 - C6), among others Q is a simple link or C (= OR) G Is - or or - NRR GCR1 is - C (= o) - zbrb, among others, where ZB is a simple Link.- or or - NH - RB is H, alkyl, cycloalkyl (C1 - C6) (C3, C8), among others.Preferred compounds are: 4 - (2 - (2 - [bis [(S) - 2 - and - (e) - ylidene - 7 - Dimethoxy - 1,2,3,11a - tetrahidropirrolo 2,1c [] [1,4] benzodiazepines - 5 - 8 - iloximetil ONA -] - pyridin - 4 - iloxi) ethyl] - (3 - (2 - [2 - (2 - (4 - il - ethoxy) ethoxy] ethoxy] - - - Propionyl) amino) - butanoate acid 3 - (2 - [bis - (2 - [(S) - 2 - and - (e) - ylidene - 7 - Dimethoxy - tetrahydro - 1,2,3,11a pyrrolo [2,1c [1],4] benzodiazepines - 5 - 8 - iloximetil ONA -] - pyridin - 4 - iloxi) ethyl] - {2 - [2 - (methoxy ethoxy) - ethoxy] ethyl} - amino) - propanoic acid among others. These compounds are useful in the treatment of cancerSE REFIERE A CONJUGADOS DE DIMEROS DE PIRROLO[1,4]BENZODIAZEPINA DE FORMULA (I) DONDE U Y U ESTAN AUSENTES O SON CADA UNO H W Y W SON CADA UNO H, OH, SH, CN, HALOGENO, ENTRE OTROS R1 Y R2 O R1 Y R2 FORMAN JUNTOS UN ENLACE DOBLE =CH2 O =CH-CH3 O SON CADA UNO H, HALOGENO O ALQUILO(C1-C6) ALK Y ALK SON ALQUILENO(C1-C6) Y E Y SON CADA UNO H U -OR, EN DONDE R Y R SON CADA UNO H, ALQUILO(C1-C6) O ARILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, CN, CF3, ENTRE OTROS M ES CH O N k ES DE 0 A 40 L1 ES UN ENLACE SENCILLO, D-ALK(C1-C6) UNIDO
