Provided is a vascular prosthesis that has various properties required of it and is highly effective in promoting the settlement of adherent vascular endothelial cells. In particular, provided is a vascular prosthesis with tubular woven structure, the prosthesis comprising an inner layer to be in contact with a blood flow, the inner layer being formed of warp and weft yarns and having a cover factor of 1800 or more, each of the warp and weft yarns comprising a microfiber multifilament yarn with a monofilament fineness of 0.50 dtex or less, the multifilament yarn comprising microfiber monofilaments having an average intersecting angle S of the monofilaments of less than 25°.