Oligomer-specific amyloid beta epitopes and antibodies

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专利权人:

ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア

发明人:

ニール・アール・キャッシュマン

申请号：

JP2012555265

公开号：

JP6190113B2

申请日:

2011.03.03

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

An isolated antibody that specifically binds to a cyclic peptide comprising the conformational epitope which has at least the amino acid sequences GSNK or SNKG, wherein the K (lysine) is solvent-exposed and wherein the antibody can specifically bind to amyloid beta is described. Methods of treating and preventing Alzheimer's disease, as well as methods to produce the antibody, are also described.

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