A use ofAntrodiacinnamomeamycelia active substance is provided. TheAntrodiacinnamomeamycelia active substance is for the treatment of chronic obstructive pulmonary disease, and is prepared by the following steps: (a)culturing aAntrodiacinnamomeamycelium in a plate media at 15 to 30℃ for 4 to 10 days； (b)inoculating the mycelium of step(a) to a flask and culturing it at 15 to 30℃ with a pH of 2 to 6 for 3 to 14 days； (c)inoculating the mycelium of step(b) to a fermenter tank and culturing it at 15 to 30℃ with a pH of 2 to 6 for 3 to 21 days, so as to obtain aAntrodiacinnamomeamycelium fermentation liquid containing saidAntrodiacinnamomeamycelium active substance.本發明提供一種樟芝菌絲體活性物質用於製備改善慢性阻塞性肺病之組合物的用途。所述樟芝菌絲體活性物質係以下列步驟製備而成：(a)取一樟芝菌絲體(Antrodiacinnamomea)於平板培養基上，於15-30℃之溫度下培養4-10天；(b)將步驟(a)培養後之樟芝菌絲體接種至一燒瓶內，於15-30℃、pH 2-6之環境培養3-14天；(c)將步驟(b)培養後之樟芝菌絲體接種於一發酵槽內，於15-30℃、pH 2-6之環境下攪拌培養3-21天，形成含有該樟芝菌絲體活性物質之一樟芝菌絲體發酵液。
