The present invention relates to a composition for raising an immune response in animal which decreases the risk of chikungunya and smallpox infection, Zika virus and smallpox infection, and/or chikungunya, Zika virus and smallpox infection. The composition comprises a pharmaceutically acceptable carrier and an attenuated poxvirus, wherein the poxvirus genome comprises a nucleic acid sequence encoding the 26S subgenomic polyprotein of chikungunya virus and/or the PrME of Zika virus.本發明係關於一種組成物，其用於在動物中產生免疫反應，從而降低屈公病與天花感染、茲卡病毒與天花感染及/或屈公病、茲卡病毒與天花感染之風險。該組成物包含醫藥學上可接受之載劑與減毒之痘病毒，其中該痘病毒基因體包含編碼屈公病病毒之26S次基因體多蛋白及/或茲卡病毒之PrME的核酸序列。
