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New condensed pyridine compounds as casein kinase inhibitors
专利权人:
Pfizer Inc.
发明人:
BUTLER, Todd,CHANDRASEKARAN, Ramalakshmi,MENTE, Scot,SUBRAMANYAM, Chakrapani,WAGER, Travis
申请号:
ES11805210
公开号:
ES2623387T3
申请日:
2011.12.06
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of Formula I: ** Formula ** in which: X is NR1 and said R1 of N is C1-4 alkyl or C3-4 cycloalkyl; Y is CR1 and said R1 of C is H or CH3; Ring A is ** Formula ** Each R2 is independently H, C1-6 alkyl, C4-10 bicycloalkyl, - (CH2) t-CN, -SO2 C1-6 alkyl, -SO2 (CH2) t C3-6 cycloalkyl , -C 1-6 alkyl-O-C 1-6 alkyl, -C 1-6 alkyl-C (O) O-C 1-6 alkyl, -C 3-6 cycloalkyl (O) O-C 1-6 alkyl, - C (O) - (O) u-C1-6 alkyl, -C (O) -C 1-6 alkyl-O-C1-6 alkyl, -C (O) - (O) or- (CH2) t- (aryl C6-10), - (CH2) t- (C6-10 aryl), -C (O) - (O) or- (CH2) t- (5-10 membered heteroaryl), - (CH2) tC ( O) -NR5R6, - (CH2) t- (5-10 membered heteroaryl), -C (O) - (O) or- (CH2) t- (3-10 membered heterocycloalkyl), - (CH2 ) t- (heterocycloalkyl of 4 to 10 members), -C (O) - (O) or- (CH2) t- (cycloalkyl of 3 to 10 members) or - (CH2) t- (cycloalkyl of between 3 and 10 members), wherein said aryl, heteroaryl, cycloalkyl and heterocycloalkyl of R2 may be substituted with up to two substituents independently selected from halogen, OH, cyano, C1-6 alkyl, -C (O) -O-C1-alkyl 3 or C1-6-O-C1-6 alkyl and in which and any alkyl, cycloalkyl and heterocycloalkyl of R2 may be further substituted with oxo when valence permits; Each R4 is F; Each R5 is independently H or C1-6 alkyl; Each R6 is independently H or C1-6 alkyl; R7 is H; n is 0, 1 or 2; Each t is independently 0, 1 or 2; and Each u is independently 0 or 1; or a pharmaceutically acceptable salt thereof.Un compuesto de Fórmula I:**Fórmula** en la que: X es NR1 y dicho R1 de N es alquilo C1-4 o cicloalquilo C3-4; Y es CR1 y dicho R1 de C es H o CH3; El anillo A es**Fórmula** Cada R2 es independientemente H, alquilo C1-6, bicicloalquilo C4-10, -(CH2)t-CN, -SO2 alquilo C1-6, -SO2(CH2)t cicloalquilo C3-6, -alquilo C1-6-O-alquilo C1-6, -alquilo C1-6-C(O)O-alquilo C1-6, -cicloalquilo C3-6-C(O)O-alquilo C1-6, - C(O)-(O)u-alquilo C1-6, -C(O)-alquilo C1-6-O-alquilo C1-6, -C(O)-(O)u-(CH2)t-(arilo C6-10), -(CH2)t-(arilo C6-10), -C(O)- (O)u-(CH2)t-(heteroarilo
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