The present disclosure relates to an interspinous omnidirectional dynamic stabilization device, including a first fixing part, a second fixing part, a connecting structure and an elastic structure, wherein the first fixing part and the second fixing part are fixedly connected to each other through the connecting structure and elastic structure, the bottoms of the first fixing part and the second fixing part are provided with one or more barbs, the elastic structure is made up of one or more U-shaped structures connected to each other, and the first fixing part and the second fixing part are provided with fixing holes respectively. The device is able to provide the maximum matching for the mobility in all directions, according to the requirements on the physiological activities of the human body, without causing stabilizing structures to be relatively displaced, or loosen and fall off. In addition, the device has a reasonably designed structure, with a small size. The device can be firmly fixed, and have a strong ability of elasticity attenuation resistance. In the device, the prosthesis has strong vertical support force at the bottom of the spinous process after implantation. Moreover, the device is fixed to the spinous processes and lamina, with the elastic structure attached to the spinous processes on either side of an interspinous space, and the bottom of the prosthesis is not forced to be close to the spinal dura mater, to reduce the risk of damaging the spinal dura mate during or after surgery.