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COMPOUNDS FOR USE IN THE TREATMENT OF MUKOZITE
专利权人:
СЕЛЛСЬЮТИКС КОРПОРЕЙШН (US)
发明人:
СКОТТ Ричард У. (US),КОРЧАК Божена (US)
申请号:
RU2013155678/04
公开号:
RU2013155678A
申请日:
2012.05.15
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method of treating and / or preventing mucositis in a mammal, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound of formula III: or a pharmaceutically acceptable salt thereof, wherein: each A independently is —C = O, —C = S or CH; each D independently represents O or S; each R independently represents hydrogen, C 1-6 alkyl, Calkoxy, halogen or halogen C 1 alkyl; each R independently represents hydrogen, C 1-6 alkyl, C 1 alkoxy, halogen or halogen C 1 alkyl; each R independently represents Orod, alkyl, alkoxy, halogen or galogenCalkil; each R independently is hydrogen, C1-6alkyl, C1-6 alkoxy, halogen or halogenoalkyl. 2. The method of claim 1, wherein the compound of formula III is a pharmaceutically acceptable salt thereof. A method for treating and / or preventing mucositis in a mammal, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: X is O or S; R is a straight or branched chain C 1-6 alkyl optionally substituted one or more groups —NH or —NH — C (═NH) NH; Y represents a bond or carbonyl; Z represents a bond or carbonyl; R represents hydrogen or a straight or branched chain C — C alkyl, optionally substituted by one or more groups —NH or —NH — C (═NH) NH; or R is —XR; R is methylene or, where methylene is substituted by straight or branched C — C alkyl, where straight or branched C — C alkyl is optional substituted by one or more groups -NH or -NH-C (= NH) NH; n is 2-101. Способ лечения и/или профилактики мукозита у млекопитающего, включающий введение нуждающемуся в этом млекопитающему терапевтически эффективного количества соединения формулы III:или его фармацевтически приемлемой соли,где:каждый A независимо представляет собой -C=O, -C=S или CH;каждый D независимо представляет собой О или S;каждый Rнезависимо представляет собой водород, Cалкил, Cалкокси, галоген или галогенCалкил;каждый
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