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COMPOSITIONS AND METHODS FOR THE EXPANSION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS
专利权人:
Magenta Therapeutics Inc.
发明人:
Anthony BOITANO,Michael COOKE,Kevin A. GONCALVES
申请号:
US16177252
公开号:
US20190314407A1
申请日:
2018.10.31
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Provided herein are compositions and methods useful for the expansion of hematopoietic stem and progenitor cells, such as those that have been genetically modified, for instance, to express a heterologous transgene. In accordance with the composition and methods described herein, hematopoietic stem and progenitor cells may be genetically modified, for example, to express transgenes encoding therapeutic proteins. Genetically modified hematopoietic stem and progenitor cells may be expanded, for instance, by treatment ex vivo with an aryl hydrocarbon receptor antagonist, and may be infused into a patient, such as a patient in need of hematopoietic stem cell transplant therapy. Thus, provided herein are methods for the treatment of various stem cell disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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