DOTSON, JENNAFER,HEALD, ROBERT ANDREW,HEFFRON, TIMOTHY,JONES, GRAHAM ELGIN,KRINTEL, SUSSIE LERCHE,MCLEAN, NEVILLE JAMES,NDUBAKU, CHUDI,OLIVERO, ALAN G.,SALPHATI, LAURENT,WANG, LAN,WEI, BINQING
申请号：
PE0014182013
公开号：
PE03142014A1
申请日:
2011.12.15
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to the PI3K Inhibitors, tricyclic compounds of formula (i), where X1 is n, CR1, - C (R1) 2o, among others x2, X3 is c, CR3, is a Heterocyclic Ring carbociclico or 5, 6, 7 links are chosen among R1, R3 h, F, CL, CH3 - CH2CH3, among others, R4 C6 C20 is aryl, heterocicl Ico has 3 - 20 Atoms in the ring, among others Mor choose between: (ii), (iii) among others.Preferred compounds are 5 - (6,6 Dimethyl 4 morpholino 8.9 - dihydro - 6h - [1,4] oxazino [3,4] - slurry - and IL - 2 - 4 - 2 - metilpirimidina) Amine, 5 - (6,6 Dimethyl 4 morpholino 8.9 - dihydro - 6h - [1,4] oxazino [3,4] - 2 - slurry - and IL - 2 Amine pyrimidine), among others. It also relates to a Pharmaceutical composition is useful for the treatment of cancer.SE REFIERE A COMPUESTOS TRICICLICOS INHIBIDORES DE LA PI3K DE FORMULA (I), DONDE X1 ES N, CR1, -C(R1)2O-, ENTRE OTROS X2 ES N, X3 ES C, CR3, A ES UN ANILLO CARBOCICLICO O HETEROCICLICO DE 5, 6 , 7 ESLABONES R1, R3 SE ELIGEN ENTRE H, F, CL, CH3, -CH2CH3, ENTRE OTROS, R4 ES ARILO C6-C20, HETEROCICLICO QUE TIENE 3 - 20 ATOMOS EN EL ANILLO, ENTRE OTROS MOR SE ELIGE ENTRE: (II), (III) ENTRE OTROS. SON COMPUESTOS PREFERIDOS 5-(6,6-DIMETIL-4-MORFOLINO-8,9-DIHIDRO-6H-[1,4]OXAZINO [3,4-e]PURIN-2-IL)- 4- METILPIRIMIDINA-2-AMINA, 5-(6,6-DIMETIL-4-MORFOLINO-8,9-DIHIDRO-6H-[1,4]OXAZINO [3,4-e]PURIN-2-IL)PIRIMIDINA-2-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y ES UTIL PARA EL TRATAMIENTO DEL CANCER.
