The present invention relates to a drug delivery device for setting and dispensing a dose of a medicament comprising: a body (12) to accommodate a drive mechanism (25) having a piston rod (27) a cartridge (30) having a barrel (32) sealed by a piston (42) slidably displaced therein along an axial direction (11 13) wherein the cartridge (30) is directly connectable with the body (12) by way of an interface (48) and wherein the barrel (32) comprises at least one radially extending portion (34 46) at its outer periphery to cooperate with at least one further functional component (18 30) of the device.
