A method for preparing a food composition for animals comprising (a) accessing at least one database that comprises a first data set relating functional genomic profile of a biofluid or tissue sample from an animal to physiological condition and optionally genotype of the animal； (b) accessing at least one database that comprises a second data set relating to effects of bioactive dietary components on functional genomic profile； (c) by use of an algorithm drawing on these data sets, processing input data defining physiological condition and optionally genotype of a subpopulation of animals to derive a nutritional formula promoting wellness of one or more animals of the subpopulation； and (d) preparing a food composition based on the nutritional formula.
