INSTYTUT BIOCHEMII I BIOFIZYKI PAN;UNIWERSYTET IM. ADAMA MICKIEWICZA W POZNANIU
发明人:
ANNA LUKASIK,PIOTR ZIELENKIEWICZ,ZOFIA SZWEYKOWSKA-KULINSKA,LESZEK PACZEK,MARIA NOWACZYK
申请号：
PT14766010
公开号：
PT3035941T
申请日:
2014.08.13
申请国别(地区):
PT
年份:
2018
代理人:
摘要：
An exemplary embodiment relates to a method of using a plant-derived miR172 molecule or its synthetic equivalent, selected from amongst miR172a or miR172b, for decreasing inflammatory processes in an organism, a method of decreasing B and T lymphocyte proliferation, as well as a method of reducing protein FAN (Factor Associated with Neutral Sphingomyelinase Activation) level. Exemplary embodiments provide a novel therapeutic method based on miRNA molecules, which through the interaction with mRNA encoding FAN protein, negatively regulate its expression and decrease the inflammatory response of the organism.
