The present invention relates to a composition for preventing or treating valve calcification, containing a dipeptidyl peptidase-4 (DPP-4) inhibitor. The DPP-4 inhibitor according to the present invention may include all of what can inhibit the expression of DPP-4 nucleotides or the activity of DPP-4 proteins, wherein: DPP-4 antibodies, sitagliptin, vildagliptin, saxagliptin, linagliptin, dutogliptin, gemigliptin, alogliptin, Anagliptin, evogliptin, Berberine, Diprotin, or Lupeol； DPP-4 mRNA anti-sense nucleotides, aptamers, small interfering RNA (siRNA), short hairpin RNA (shRNA), and microRNA (miRNA), or RNA interference (RNAi)； or the like can be used.La presente descripción se refiere a una composición para prevenir o tratar la calcificación valvular, que contiene un inhibidor de dipeptidil peptidasa-4 (DPP-4). El inhibidor de DPP-4 de acuerdo con la presente divulgación puede incluir todo lo que puede inhibir la expresión de nucleótidos de DPP-4 o la actividad de las proteínas DPP-4, en donde: se pueden utilizar anticuerpos DPP-4, sitagliptina, vildagliptina, saxagliptina, linagliptina, dutogliptina, gemigliptin, alogliptin, Anagliptin, evogliptin, Berberine, Diprotin o Lupeol； Nucleótidos antisentido de DPP-4-mRNA, aptámeros, ARN de pequeña interferencia (siRNA), ARN de horquilla corta (shRNA) so y microARN (miRNA) o interferencia de ARN (RNAi)； o similares.
