Joacim Elmen,Claes Wahlestedt,Zicai Liang,Anders M. Sorensen,Henrik Orum,Troels Koch
申请号：
US14177458
公开号：
US09297010B2
申请日:
2014.02.11
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention is directed to novel double-stranded short interfering (siRNA) analogs comprising locked nucleic acid (LNA) monomers. Such compounds induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). The compounds disclosed herein has improved properties compared to non-modified siRNAs and may, accordingly, be useful as therapeutic agents, e.g., in the treatment of various cancer forms. More particularly, the present invention is directed to siRNA analogs comprising a sense strand and an antisense strand, wherein each strand comprises 12-35 nucleotides and wherein the siRNA analogs comprise at least one locked nucleic acid (LNA) monomer.
