PROBLEM TO BE SOLVED: To provide compositions which promote cornification of the skin, maintain moisture of the skin and improve trouble of the skin such as formation of wrinkles, the anomaly of texture and the rough skin, and further, to obtain formulations which promote production of filaggrins, loricrins, peptidylarginine deiminases (PADI-1), histidases or the like, promote cornification and keep the beautiful skin.SOLUTION: A cornification promoter, filaggrin production promoter, loricrin production promoter, PADI-1 production promoter and histidase production promoter include the enzymatic decomposition product of a water-insoluble protein included in a pearl and/or a shell as an active constituent.COPYRIGHT: (C)2013,JPO&INPIT【課題】本発明の目的は、皮膚の角化を促進し、皮膚の水分を維持し、シワの形成、肌理の不正常、荒れ肌等の皮膚のトラブルを改善する組成物に関する。さらにはフィラグリン、ロリクリン、ペプチジルアルギニンデイミナーゼ-1(PADI-1)、ヒスチダーゼ等の産生を促進し、角化を促進して美しい皮膚を保つ製剤を得ることにある。【解決手段】真珠および/または貝殻に含まれる水不溶性タンパク質の酵素分解物を有効成分とする角化促進剤、フィラグリン産生促進剤、ロリクリン産生促進剤、PADI-1産生促進剤及びヒスチダーゼ産生促進剤【選択図】図1
