您的位置: 首页 > 农业专利 > 详情页

COMPOSITION OF MICROPARTICLES FOR DELIVERY OF A MEDICINE FOR ANTI-INFECTIOUS MOLECULE FOR TREATMENT OF INFECTIOUS DISEASES
专利权人:
ПИРАМАЛ ЭНТЕРПРАЙЗИС ЛИМИТЕД (IN)
发明人:
ЧХИМОТЕ Геетанджали Чхандрашекхар (IN),МАХАДЖАН Гириш Бадринатх (IN),ВАСУДЕВАН Аравиндан (IN),ХАРИХАРАН Сиварамакришнан (IN)
申请号:
RU2013109384/15
公开号:
RU2013109384A
申请日:
2011.08.04
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. The composition in the form of microparticles containing a compound of formula I and a biodegradable lipid for drug delivery, where the ratio of the compounds of formula I and lipid is from 1:15 to 1:25; where the composition is biodegradable and respirable. 2. The microparticle composition according to claim 1, where the compound of formula I is from 1 to 5 wt.% Of the composition. The microparticle composition according to claim 1 or 2, wherein the biodegradable lipid is dipalmitoylphosphatidylcholine (DPPC). The microparticle composition according to claim 1, where the particle size of the microparticles is in the range from 0.5 to 10 microns. The microparticle composition according to claim 4, wherein at least 90% of the microparticles have a particle size of less than 10 microns. The microparticle composition according to claim 1, wherein the composition is an aqueous liposome dispersion. The composition in the form of microparticles according to claim 1, where the composition has a pH from 6 to 7.8. The microparticle composition according to claim 1, where for the specified composition the phase transition temperature is from 41 to 43 ° C. A method of obtaining a microparticle composition containing a compound of formula I according to claim 1 and dipalmitoylphosphatidylcholine (DPPC), where the ratio of the compounds of formula I and DPPC is from 1:15 to 1:25, where the method includes the steps in which: (a) dissolving the compound of formula I and DPPC in 3-15 ml of chloroform to obtain a solution; (b) add 20-45 ml of methanol to the solution of step (a) and mix thoroughly to ensure uniformity; (c) add 20-50 ml of simulated pulmonary fluid ( SLF) to the solution of step (b); (d) the solvents are evaporated; (e) the volume obtained is adjusted d in step (d), up to 30 ml using SLF and centrifuged at 15000-35000 G at 4 ° С for 10 min to obtain a precipitate; (f) re-suspend the precipitate obtained in step (e) in SLF1. Состав в виде микрочастиц, содержащий с
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充