Methods and apparatuses for quality control in image space for processing with an input data set are disclosed. A method includes providing an image object, including multiple voxels, and an input data set. A data model is determined from the image object. A cumulative distribution function (CDF) for the input data set is determined from the data model and the input data set based on a plurality of projections. The CDF is transformed to an image cumulative distribution function (ICDF) in object space. The ICDF represents a number of standard deviations associated with each voxel of the image object. The output of the ICDF is displayed. A nuclear imaging system and a computer readable storage medium are also disclosed. Techniques disclosed herein facilitate efficient quality control for tomographic image reconstruction.
