A medicine packet dispensing device with an automatic reminder function comprises a box having a medicine discharge hole; a control device arranged in the box; and a medicine discharge module arranged in the box. The control device includes a processor used to set at least one medication time; at least one reminder unit controlled by the control device to emit an alert according to the medication time; and a plurality of medicine discharge operating interfaces used to input an instruction to the processor to enable the processor to generate a medicine discharge signal to the medicine discharge module. The medicine discharge module has medicine packet accommodation spaces for accommodating medicine packets and sends one medicine packet to the medicine discharge hole according to the medicine discharge signal. The present invention reminds the user to take medicine at designated times and allows the user to change the medication times.