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ANTICORPS STABLES ET SOLUBLES INHIBANT LE TNF-ALPHA
专利权人:
ESBATech; an Alcon Biomedical Research Unit LLC
发明人:
申请号:
EP17167592.9
公开号:
EP3260465A1
申请日:
2006.06.06
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFa, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFa, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFa-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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