The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFa, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFa, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFa-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
