THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
发明人:
Neil Andrew Robert Gow,Fiona Marion Rudkin,Lars-Peter Erwig,Allan Jensen
申请号：
US15556145
公开号：
US20180037640A1
申请日:
2016.03.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This invention relates to recombinant human antibody molecules. The antibodies bind fungal antigens, for example from Candida spp. Human antibody encoding genes targeting clinically relevant Candida epitopes have been isolated from single B cells from carefully selected donors and screened with specified types of protein or cell wall extract. The panel of purified, fully human recombinant IgG1 mAbs generated displayed a diverse range of specific binding profiles and demonstrated efficacy in a disease model. The fully human mAbs and derivatives thereof have utility in the generation of diagnostics, therapeutics and vaccines.
