PURPOSE: A composition containing piperazine with an effect of suppressing serotonin-5-HT6 is provided to use as a therapeutic agent for central nervous system(CNS) diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating central nervous system(CNS) diseases contains piperazine compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The central nervous system diseases are Alzheimer disease, obesity, schixopherenia, depression, neuropsychological disorder and affective disorder. A health food composition for preventing and treating CNS diseases contains piperazine compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient.본 발명은 세로토닌 5-HT6에 대한 저해 활성 효과를 나타내어 치매 (dementia)를 포함하는 알쯔하이머병 (Alzheimer disease)에 의한 인지기능 및 기억손상, 대사이상 및 비만 (obecity), 정신분열병 (schizopherenia), 우울증 (depression), 신경심리학적 이상(treatment of neuropsychological disorder), 정동장애 (affective disorder), 스트레스에 의한 기억손상과 같은 중추신경계(CNS, central nervous system) 질환의 예방 및 치료제로서 유용한 피페라진 화합물을 유효성분으로 함유하는 조성물에 관한 것이다.
