Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
Steeves, Rita,Lutz, Robert,Chari, Ravi,Xie, Hongsheng,Kovtun, Yelena,Widdison, Wayne
申请号：
AU2010212291
公开号：
AU2010212291C1
申请日:
2010.08.12
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2010212291C120121129.pdf#####ABSTRACT 5 1. A compound of formula 5. E MeO N 10 MeO*HON O 5 15 wherein X is a linear or branched alkyl, alkenyl or alkynyl group bearing 2 to 20 carbon atoms, Y is a cycloalkyl or cycloalkenyl group bearing 3 to 10 carbon atoms, Z is a substituted or unsubstituted aromatic group bearing 6 to 10 carbon atoms or a substituted or unsubstituted heterocyclic group wherein the hetero atom is selected from N, 0 or S, and I , m and n are each 0 or 1, provided that they are all not 0 at the same 20 time, and E together with the carbonyl group forms an active ester such as N-hydroxy succinimidyl and sulfosuccinimidyl esters, N-hydroxy phthalimidyl ester, N-hydroxy sulfophthalimidyl ester, ortho-nitrophenyl ester, para-nitrophenyl ester, 2,4dinitrophenyl ester, 3-sulfonyl-4-nitrophenyl ester, 3-carboxy-4-nitrophenyl ester, pentaflurophenyl ester, and sulfonyl tetrafluorophenyl ester. 25 2362540_1 (GHMatters) 9/08/10
