СУЛА Оливье (FR),СУЛА Жерар (FR),ТОННАР Джефф (FR),ЖЕССЛЕР Александр (FR)
申请号：
RU2014108829/15
公开号：
RU2014108829A
申请日:
2012.08.09
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A composition in a form suitable for injection of an aqueous solution having a pH value ranging from 6.0 to 8.0 and comprising at least: a) a basal insulin, which is the isoelectric point pI is in the range of from 5.8 to 8.5 b) dextran-substituted carboxylate radicals charge carriers and hydrophobic radicals of formula I or formula II: wherein R represents -OH or is selected from the group consisting of radicals :-( f- [a] -COOH) -( g - [B] -k- [D]), where D comprises at least one alkyl chain having at least 8 carbon atoms n is degree of substitution of the glycosidic residues groups -f- [A] -COOH, wherein 0,1≤n≤2 m denotes the degree of substitution of the glycosidic residues groups -g- [B] -k- [D], wherein 0
