Joshua Robert Giguere,Helge Alfred Reisch,Sergio Sandoval,Jake Larry Stymiest
申请号：
US13711288
公开号：
US08921556B2
申请日:
2012.12.11
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present disclosure provides improved methods for N-dealkylation of tertiary amines, including methods for N-demethylation of alkaloids and opioids, in which the dealkylation reaction is carried out in a solvent comprising a tertiary alcohol. The present disclosure also provides improved processes for preparing semi-synthetic opioids that incorporate the disclosed methods for N-dealkylation of tertiary amines.
