A kind of composition is described, there is Aripiprazole pro-drug particle swarm and (b) at least one surface stabilizer of volume basal granule degree (Dv50) less than 1000nm including (a), it includes the absorbed component adsorbed on Aripiprazole pro-drug particle surface and the free components that can be used for Aripiprazole pro-drug solubilising.Surface stabilizer is used to produce the purpose for introducing preparation with pro-drug than providing the free surface stabilizer of most suitable quantity.Also description uses the treatment method of above-mentioned composition.
