HIRD, ALEXANDER,BELMONTE, MATTHEW ALAN,YANG, WENZHAN,SECRIST, JOHN PAUL,ROBBINS, DANIEL WILLIAM,KAZMIRSKI, STEVEN LEE,WU, DEDONG,PENG, BO,JOHANNES, JEFFREY,LAMB, MICHELLE LAURAE,YE, QING,ZHENG, XIAOLA
申请号:
CA3020378
公开号:
CA3020378A1
申请日:
2017.04.21
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta- 1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I) and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia- 5,6,12,13,22-pentaazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta- 1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.